Multi-species Ontologies of the Craniofacial Musculoskeletal System.

Mejino, Jose L V and Detwiler, Landon T and Cox, Timothy C and Brinkley, James F (2016) Multi-species Ontologies of the Craniofacial Musculoskeletal System. In: Proceedings of the Joint International Conference on Biological Ontology and BioCreative (ICBO). IP03.

[thumbnail of nihms850287.pdf]
Preview
Text
nihms850287.pdf

Download (807kB) | Preview

Abstract

We created the Ontology of Craniofacial Development and Malformation (OCDM) [1] to provide a unifying framework for organizing and integrating craniofacial data ranging from genes to clinical phenotypes from multi-species. Within this framework we focused on spatio-structural representation of anatomical entities related to craniofacial development and malformation, such as craniosynostosis and midface hypoplasia. Animal models are used to support human studies and so we built multi-species ontologies that would allow for cross-species correlation of anatomical information. For this purpose we first developed and enhanced the craniofacial component of the human musculoskeletal system in the Foundational Model of Anatomy Ontology (FMA)[2], and then imported this component, which we call the Craniofacial Human Ontology (CHO), into the OCDM. The CHO was then used as a template to create the anatomy for the mouse, the Craniofacial Mouse Ontology (CMO) as well as for the zebrafish, the Craniofacial Zebrafish Ontology (CZO).

Item Type: Book Section
Subjects: All Projects > Ontology of Craniofacial Development and Malformation
Divisions: University of Washington > Department of Biological Structure
Depositing User: Jim Brinkley
Date Deposited: 17 Jul 2018 23:58
Last Modified: 17 Jul 2018 23:58
URI: http://sigpubs.si.washington.edu/id/eprint/312

Actions (login required)

View Item View Item