Evaluating spatial normalization methods for the human brain

Smith, Veronica S and Shapiro, Linda G and Hanlon, D. and Martin, Richard F and Brinkley, James F and Poliakov, Andrew V and Ojemann, George A and Corina, David P (2005) Evaluating spatial normalization methods for the human brain. In: 27th Annual Conference of the IEEE Engineering and Biology Society (EMBS). pp. 5331-5334.

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Cortical stimulation mapping (CSM) studies have shown cortical locations for language function are highly variable from one subject to the next. If individual variation can be normalized, patterns of language organization may emerge that were heretofore hidden. In order to uncover this pattern, computer-aided spatial normalization to a common atlas is required. Our problem was how to determine which spatial normalization method was best for the given research application. We developed key metrics to measure accuracy of a surface-based (Caret) and volume-based (SPM2) method. We specified that the optimal method would i) minimize variation as measured by spread reduction between CSM language sites across subjects while also ii) preserving anatomical localization of all CSM sites. Eleven subjects' structural MR data and corresponding CSM site coordinates were registered to the colin27 human brain atlas using each method. Local analysis showed that mapping error rates for both methods were highest in morphological regions with the greatest difference between source and target. Also, SPM2 mapped significantly less type 2 errors. Although our experiment did not show statistically significant global differences between the methods, our methodology provided valuable insights into the pros and cons of each.

Item Type: Book Section
Uncontrolled Keywords: spatial normalization
Subjects: All Projects > Brain Mapping
Depositing User: Jim Brinkley
Date Deposited: 19 May 2006
Last Modified: 25 Jul 2017 21:40
URI: http://sigpubs.si.washington.edu/id/eprint/185

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