Ontology-based federated data access to human studies information.

Sim, Ida and Carini, Simona and Tu, Samson W and Detwiler, Landon T and Brinkley, James F and Mollah, Shamim A and Burke, Karl and Lehmann, Harold P and Chakraborty, Swati and Wittkowski, Knut M and Pollock, Brad H and Johnson, Thomas M and Huser, Vojtech (2012) Ontology-based federated data access to human studies information. In: Proceedings, Fall Symposium of the American Medical Informatics Association. pp. 856-865.

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Human studies are one of the most valuable sources of knowledge in biomedical research, but data about their design and results are currently widely dispersed in siloed systems. Federation of these data is needed to facilitate large-scale data analysis to realize the goals of evidence-based medicine. The Human Studies Database project has developed an informatics infrastructure for federated query of human studies databases, using a generalizable approach to ontology-based data access. Our approach has three main components. First, the Ontology of Clinical Research (OCRe) provides the reference semantics. Second, a data model, automatically derived from OCRe into XSD, maintains semantic synchrony of the underlying representations while facilitating data acquisition using common XML technologies. Finally, the Query Integrator issues queries distributed over the data, OCRe, and other ontologies such as SNOMED in BioPortal. We report on a demonstration of this infrastructure on data acquired from institutional systems and from ClinicalTrials.gov.

Item Type: Book Section
Subjects: All Projects > Clinical Research Data Management
Divisions: University of Washington > Department of Biological Structure
Depositing User: Jim Brinkley
Date Deposited: 17 Jul 2018 23:38
Last Modified: 09 May 2019 23:34
URI: http://sigpubs.si.washington.edu/id/eprint/309

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