Mejino, Jose L V and Detwiler, Landon T and Cox, Timothy C and Brinkley, James F (2016) Multi-species Ontologies of the Craniofacial Musculoskeletal System. In: Proceedings of the Joint International Conference on Biological Ontology and BioCreative (ICBO). IP03.
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Abstract
We created the Ontology of Craniofacial Development and Malformation (OCDM) [1] to provide a unifying framework for organizing and integrating craniofacial data ranging from genes to clinical phenotypes from multi-species. Within this framework we focused on spatio-structural representation of anatomical entities related to craniofacial development and malformation, such as craniosynostosis and midface hypoplasia. Animal models are used to support human studies and so we built multi-species ontologies that would allow for cross-species correlation of anatomical information. For this purpose we first developed and enhanced the craniofacial component of the human musculoskeletal system in the Foundational Model of Anatomy Ontology (FMA)[2], and then imported this component, which we call the Craniofacial Human Ontology (CHO), into the OCDM. The CHO was then used as a template to create the anatomy for the mouse, the Craniofacial Mouse Ontology (CMO) as well as for the zebrafish, the Craniofacial Zebrafish Ontology (CZO).
| Item Type: | Book Section |
|---|---|
| Subjects: | All Projects > Ontology of Craniofacial Development and Malformation |
| Divisions: | University of Washington > Department of Biological Structure |
| Depositing User: | Jim Brinkley |
| Date Deposited: | 17 Jul 2018 23:58 |
| Last Modified: | 17 Jul 2018 23:58 |
| URI: | http://sigpubs.si.washington.edu/id/eprint/312 |
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